Ampoule Filling and Sealing Machine
Main usage and features
The machine is the new generation multi-position drawbench filler. Matrix bottle delivering device is adopted in the new machine which makes the ampoule filling more stable and gains lower bottle broken ratio. A new clutch device is installed to the hopper which can make non-stop ampoule delivering to reduce ampoule wasting. It also has high stability auto-stopping device when no bottle in filling position. The bottle output device abandoned the traditional delivering method, using a better way to settle the bottles to acquire a higher finish product ratio.
Technical Data
| Specification | 1-2ml |
| Output | 9000-12000dosage/hour |
| Power | 380V/0.55kw |
| Contour Dimension | 170*950*131cm |
| Weight | 300kg |
Ampoule Filling and Sealing Machine
Introduction This ampoule filling and sealing machine is a machine recently developed by our factory in accordance with world tide and domestic situation. The machine can be used for ampoules of 1ml, 2ml, 5ml, and can fill nitrogen and seal8 ampoules simultaneously. Air purifying device of many forms can be equipped on top of the machine according to the requirement of customer. This machine can be solely used, and can be used together with ultrasonic wave cleaning machine and sterilizing tunnel drying machine as well. It has merits of high production rate, high filling precision, high qualified rate for sealing, stable and reliable running, low noise, easy and fast replacing of standard parts, and no need to adjust repeatedly, it is simplified and humanized. Technical data
| Number of filling heads | 12 | |
| Ampoule | ||
| Production capability | 1,2ml | 32000pcs/h |
| 5ml | 25000pcs/h | |
| 10ml | 19000pcs/h | |
| rated production capability | 90% above production capability | |
| loading accuracy | ± 2% (Glass filling pump) | |
| percent of pass | ≥ 98% | |
| Power consumption | 2.4kw (Ac 380V/50Hz) | |
| Nitrogen consumption | 3m3/h | |
| Fuel gas Consumption | City gas | 0.6m3/h |
| LPG | 0.25m3/h | |
| Oxygen Consumption | Use City gas | 1.8m3/h |
| Use LPG | 2.6m3/h | |
| Suction requirement | 0.6m/s | |
| External dimension: L×W×H（mm） | 3600×2100×2450 | |
| Net weight (kg） | 2500 | |
Introduction
This sterilizer is a kind of sterilizing device in full accordance with GMP of the latest version, US FDA and EU cGMP regulations. This equipment is used for the sterilization and depyrogenation of heat-resistant materials that cannot be used for moist heat sterilization, such as glass bottles, vials, glass vessels, metal containers and equipment parts. This equipment can be supplied with a set of documents in accord of FDA, which is the preferred equipment for biological and pharmaceutical companies.
Technical data
| Equipment Model | Door | Chamber Dimension | Overall | Weight | Control | Driver Power | |
| Volume | Dimension | (Unloading) | Power | ||||
| mm | mm | Kg | 220V/Kw | 380V/Kw | |||
| GDS-0.24 | GCS-0.24 | 2 | 500*740*650/0.24m3 | 1770*1050*1730 | 750 | 0.5 | 11 |
| GDX-0.36 | GCX-0.36 | 2 | 600*750*800/0.36m3 | 1870*1060*2082 | 800 | 0.5 | 11 |
| GDE-0.6 | GCE-0.6 | 2 | 800*800*1000/0.64m3 | 2070*1110*2266 | 900 | 0.5 | 15 |
| GDH-0.8 | GCH-0.8 | 2 | 800*1040*1000/0.83m3 | 2070*1310*2266 | 1100 | 0.5 | 18 |
| GDA-1.0 | GCA-1.0 | 2 | 800*1260*1000/1.01m3 | 2070*1560*2266 | 1300 | 0.5 | 21 |
| GDB-1.2 | GCB-1.2 | 2 | 1000*1000*1200/1.20m3 | 2270*1310*2466 | 1500 | 0.5 | 21 |
| GDF-1.5 | GCF-1.5 | 2 | 1000*1250*1200/1.50m3 | 2270*1560*2466 | 1650 | 0.5 | 28 |
| GDM-2.0 | GCM-2.0 | 2 | 1000*1700*1200/2.04m3 | 2270*2010*2466 | 1800 | 0.5 | 34 |
| GDG-2.5 | GCG-2.5 | 2 | 1000*2100*1200/2.52m3 | 2270*2410*2466 | 2000 | 0.5 | 39 |
| GDT-3.0 | GCT-3.0 | 2 | 1000*2500*1200/3.00m3 | 2370*2300*2622 | 2200 | 0.5 | 46 |
| GDL-4.0 | GCL-4.0 | 2 | 1300*2050*1500/4.00m3 | 2620*2360*2622 | 2400 | 0.5 | 54 |
| GDK-5.0 | GCK-5.0 | 2 | 1300*2492*1500/4.86m3 | 2620*2800*2622 | 2600 | 0.5 | |
Introduction The machine has triple blender, hydraulic lift cover, high-speed homogeneity blender (Speed is 0-3500r/min, frequency speed regulation) and low-speed scraper blender (Speed is 0-40r/min, frequency speed regulation). Fast-cutting vortex emulsification blender is used in the homogenizer part, which can scrape in a low speed and automatically blend and snuggle up to the bottom and wall of boiler. The machine draws powder material by the way of vacuum in order to prevent the powder flying. The whole working procedure is operated in the condition of vacuum in order to prevent the material coming into being bubble after high-speed blending and reach the request of sanitation and asepsis. CIP cleaning system is equipped in this system. The contact part of vessel and material is made from SUS316L material. Mirror finish of the inside surface is 300EMSH. In order to ensure the stabilization of the control, the vacuum pump is the products of Germany Siemens Company, the button is produced by Japan Fuji Company, the transducer is the product of Japan Matsushita Electric Industries and the electro-control part is the product of Siemens Company. The machine is made completely according to the GMP request, which is the most advanced and most perfect cream production equipment. The machine is specially designed adopting advanced technology of oversea according to the cosmetic and ointment production technology. The machine is made up of pretreatment boiler, vacuum emulsification blending boiler, vacuum pump, hydraulic system and worktable. The machine has easy operation, steady capability, good homogeneity, high efficiency, reasonable structure, small volume and high automation level and easily clean. Technical data
| Model | Effective Capacity | Emulsify | Agitator | Outside Dimension | The Merit Rate (KW) | |||||
| KW | r/min | KW | r/min | Length | Width | Height | Max H | |||
| 20 | 20 | 2.2 | 0-3500 | 0.37 | 0-40 | 1800 | 1600 | 1850 | 2700 | 5 |
| 50 | 50 | 3 | 0-3500 | 0.75 | 0-40 | 2700 | 2000 | 2015 | 2700 | 7 |
| 100 | 100 | 3 | 0-3500 | 1.5 | 0-40 | 2920 | 2120 | 2200 | 3000 | 10 |
| 150 | 150 | 4 | 0-3500 | 1.5 | 0-40 | 3110 | 2120 | 2200 | 3100 | 11 |
| 200 | 200 | 5.5 | 0-3500 | 1.5 | 0-40 | 3150 | 2200 | 2200 | 3100 | 12 |
| 350 | 350 | 7.5 | 0-3500 | 2.2 | 0-40 | 3650 | 2650 | 2550 | 3600 | 17 |
| 500 | 500 | 7.5 | 0-3500 | 2.2 | 0-40 | 3970 | 2800 | 2700 | 3950 | 19 |
| 750 | 750 | 11 | 0-3500 | 4 | 0-40 | 3780 | 3200 | 3050 | 4380 | 24 |
| 1000 | 1000 | 15 | 0-3500 | 4 | 0-40 | 3900 | 3400 | 3150 | 4550 | 29 |
| 1500 | 1500 | 18.5 | 0-3500 | 7.5 | 0-40 | 4000 | 4100 | 3750 | 5650 | 42 |
| 2000 | 2000 | 22 | 0-3500 | 7.5 | 0-40 | 4850 | 4300 | 3600 | / | 46 |
Eye Drop Filling, plugging and Capping Machine
Introduction
This eye drop filling and capping machine mainly used for eye drop production line. This machine use advanced microcomputer to control peristaltic pumps filling in high accuracy. Technical flow process: bottles feeding with sectorial star-wheel, 4 heads to fill, stoppers feeding in 4 tracks, caps feeding in 4 tracks, 4 heads for capping. These working process can insure the products in high quality. Machine mainly consists of unscrambler, bottle feeding part, sectorial star-wheel, filling part, stopper part and capping part.
Characteristic
Manipulator moves the nozzles to improve the stopper rate when using thin edge nozzles.
Single chip system controlled peristaltic pump filling, dosage precision is high, can adjust the dosage without stopping the machine.
Filling, stopper and capping monoblock machine. Space saving and simple structure. Good appearance and easy to clean.
Graduator positioning is precise, running is stable can fill bottles of different size.
Touch panel control panel, easy operation and high automation degree. Speed adjustable by inverter.
No bottle no filling; auto stops when no caps.
Technical data
| Suitable bottle range | 5~30mlplastic pump (change the proper change part) |
| Production capacity | 70-120bts/min, 5-20ml bottle Dosage 5-20ml |
| Filling error | ≤1.5％ |
| Auto stopper ratio | ≥99.5% |
| Bottle breakage ratio | ≤0.5% |
| Power supply | 220V 50Hz |
| Power | 1.3Kw |
| Filling head | 2-head filling |
| Compressed air pressure | 0.4~0.6Mpa 25~35 L/min |
| Single machine noise | ≤70dB |
| Weight | ~800Kg |
| Dimension | 2620×1250×1480(mm) |
Service scope:
Features of compounding system
| Oral liquid preparation system |
| Sterile compounding system |
| Extraction compounding system |
| Cream and eye ointment compounding system |
- For multi-tank preparation system, advanced adapter plate design process is adopted. Tank cleaning can be completely independent of pipe, so as to avoid leakage of materials, pollution and risk of false operation.
- Piping and equipment meets requirements of GMP production, without blind pipe and dead ends. Installation of equipment and accessories facilitates disassembly, maintenance and repair.
- Control system meets operation requirements of production process, and automatic control of online cleaning, sterilization, material transfer, etc. can be realized. Relevant parameters of preparation system can be monitored and recorded in real time, to ensure quality tracking and tracing.
- After detailed design and before construction, the whole system will be three-dimensional designed according to layout of field equipment.
Powder filling, plugging and capping machine (PT-KFG series)
Introduction
This powder filling machine is a new generation of high speed screw filling machine which our company developed based on the former 4 head powder filling machine. It adopts guaduator system to conduct high speed filling process.
Characteristic
Filling speed is high, servo motor driven, the filling precision is high.
Plate type conveyor, star wheel and graduator linked together firmly, stable running and precise positioning.
Different type of filling auger meet different the needs of filling different powder.
PLC control the whole process, high automation degree.
Touch panel control, can set the filling dosage without stopping the machine.
Speed controlled by inverter.
Falling bottle auto reject; no bottle, no filling; no stoppers, auto stops; insufficient stoppers alarm
Auto counting function.
CE certified, standard electric installation, safety guarantee on operation.
Auto stop filling when filling auger touches filling nozzle and alarms.
Easy to change the change part, filling dosage adjustable.
Optional acrylic glass hood, laminar flow, sealed air outlet device.
Optional pre-fill and after-fill nitrogen filling device.
The whole machine is designed according to GMP requirements.
Technical data
| Suitable bottle range | 7~30ml (tubular or molded vial) |
| Production capacity | 280~300bts/min, 10ml bottle Dosage 1g |
| Power supply | 220V 50Hz |
| Total power | 3kw |
| Filling error | ≤2% |
| Auto stoppering ratio | ≥99.7% |
| Bottle breakage ratio | ≤0.1% |
| Single machine noise | ≤70dB |
| Vacuum degree | -6x10-2Mpa, 14m3/h |
| Weight | 800kg |
| Dimension | 2850×1000×1800(mm) |
Powder filling, plugging and capping machine (PT-KFS series)
Brief introduction
This powder filling machine is a kind of screw type sterile powder filling machine. It adopts two tracks, cylinder positioning, 2 head screw filling and 2 roller stopper. The servo motor controls the filling auger precisely.
Characteristic
2 long chain plate conveyor, cylinder positioning, 2-head screw filling, 2-roller stopper, so the machine length is shortened.
Different types of filling auger meet requirements of powders with different fluidity.
Touch panel control can set the filling dosage without stopping the machine.
Speed control by inverter.
Falling bottle auto reject; no bottle, no filling; no stoppers, auto stops; insufficient stoppers alarm.
Auto counting function.
CE certified, standard electric installation, safety guarantee on operation.
Auto stop filling when filling auger touches filling nozzle and alarms.
Easy to change the change part. Easy to operate and disassemble. Easy to clean the key part.
Optional acrylic glass hood, laminar flow, sealed air outlet device.
The whole machine is designed according to GMP requirements.
Technical data
| Suitable bottle range | 7~30ml (Tubular vial or molded vial) |
| Production capacity | 200-250bts/min, 7ml bottle Dosage 1g |
| Power supply | 220V 50Hz |
| Power consumption | 1kw |
| Compressed air pressure | 0.4~0.6Mpa 25~35 L/min |
| Filling error | ≤2% |
| Auto stoppering ratio | 99.90% |
| Speed control | Speed control by inverter |
| Single machine noise | ≤70dB |
| Weight | 800kg |
| Dimension | 2270×1050×1500（mm） |
Soft Gel Encapsulation Machine
Introduction
Different from the two-step manufacturing (shaping and filling) of hard gelatin capsule, the soft gelatin capsule is made on a rotating mould in a continuous one-step operation. Gelatin skin made of gelatin and glycerol passed through two die rolls facing each other and continuously rotating in reverse cycles and forms its shape in the mould cavity. The size and shape of the soft gelatin capsule are determined by the mould cavity. Material filling and sealing of gelatin skin is carried out in the same time so that the filling process ends right before the finish of sealing.
Feature
- The soft gelatin capsule has tidy and beautiful appearance. Compared to tablets pills, it features faster disintegration speed, higher bioavailability and convenient ingestion, storage and taking along.
- The capsule can cover unpleasant odor of the medicine.
- The capsule can be made into instant-effective, slow-releasing, enteric coated or gastro soft gelatin capsules.
- Both medicine with dosage form of higher oil concentration that cannot be easily made into tablets or pills and small-dosage principle agent that is not water-soluble and hard to be ingested in the digestive tract can be dissolved in proper amount of oil and made into soft gelatin capsules.
- Light-sensitive and unstable drugs can be filled into opaque light proof capsules to improve the stability and prevent the drug from been affected by moisture, oxygen and light in the air.
- Completely sealed package ensures the intactness of its content and provides counter fake function.
- The soft gelatin capsule can be used to make, cosmetics and paintball for simulated shooting, etc.
| Model/Data | 100 | 200 | 250 | 315 |
| Mould Size (mm) | Dia. 80 X W: 100 | Dia. 113 X W: 200 | Dia. 150 X W: 250 | Dia. 157 X W: 315 |
| Mould Revolution (RPM) | 0-5 Rpm (adjusted variable speed) | 0-5 Rpm (adjusted variable speed) | 0-5 Rpm (adjusted variable speed) | 0-5 Rpm (adjusted variable speed) |
| Volume of Plunger Pump | 0-1.5 ml (adjustable continuously) | 0-2 ml (adjustable continuously) | 0-2 ml (adjustable continuously) | 0-2 ml (adjustable continuously) |
| Pump Accuracy | +/-0.5% (filling volume not less than 500 mg) | +/-0.5% (filling volume not less than 500 mg) | +/- 0.5% ~ 1.5% | +/- 0.5% ~ 2% |
| Pump Type | 8 plunger pump | 14 plunger pump | 20 plunger pump | 24 plunger pump |
| Production Capacity | 4#OV capsule 30,000pills/hrs (4.0 RPM) | 8#OV capsule 62,400pills/hrs (4.0RPM) | 8#OV capsule 115,440pills/hrs(4.0RPM) 20#OB capsule 58,800(4.0RPM) | 8#OV capsule 150,960 pills/hrs (4.0RPM) |
| Power Supply | 1.8 Kw, 360V 3 phases (can be modified as user’s requirement.) | 12 Kw, 360V 3 phases (can be modified as user’s requirement.) | 12 Kw, 360V 3 phases (can be modified as user’s requirement.) | 12 Kw, 360V 3 phases (can be modified as user’s requirement.) |
| Weight | 400 Kg | 1,300 Kg | 1,500 Kg | 1,500 Kg |
| Dimension (LxWxH)mm | 1440x660x1350 | 2000x910x1900 | 2040x960x1900 | 2100x1130x1900 |
Steam Sterilizer (ampoule/vial)
Introduction
Ampoule Steam Sterilizer is mainly used for the sterilization, leak test and washing of ampoule, syrup and IV solution with small capacity. It adopts pressure steam as sterilizing medium to achieve the uniform sterilization between 105℃～127℃. This sterilizer adopts heating mode of displacement and exhausting from multi-points to ensure the through elimination of cold air in chamber, uniform and rapid heating and eliminate the dead corner caused by the existing cold air. Leak test by vacuum and color water is adopted to improve the detection rate of waste after sterilization, meanwhile provides the documents system that meets 2010 version GMP requirement.
Technical data
| Equipment Model | Door | Trolley | Chamber Dimension | Overall | Weight | Clean | Deionized | Clean | C A | Control | Driver | Color |
| Volume | Dimension | (Unloading) | Steam | Water | Water | Power | Power | Water | ||||
| (Option) | ||||||||||||
| mm | mm | Kg | Kg/cycel | L/cycel | L/cycel | Nm3/h | 220V/Kw | 380V/Kw | L/cycel | |||
| XG1.SDE-0.6 | 2 | 1 | 1200*610*910/0.67m3 | 1490*1390*1940 | 1500 | 28 | 260 | 230 | 5.8 | 0.5 | 2 | 500 |
| XG1.SDH-0.8 | 2 | 1 | 1450*610*910/0.80m3 | 1742*1390*1940 | 1600 | 34 | 310 | 280 | 7.7 | 0.5 | 2.9 | 650 |
| XG1.SDA-1.0 | 2 | 2 | 1700*610*910/0.94m3 | 1992*1390*1940 | 1800 | 48 | 350 | 280 | 9.6 | 0.5 | 2.9 | 850 |
| XG1.SDB-1.2 | 2 | 1 | 1500*680*1180/1.20m3 | 1812*1465*1940 | 2300 | 58 | 400 | 280 | 12 | 0.5 | 2.9 | 1000 |
| XG1.SDC-1.5 | 2 | 2 | 1870*680*1180/1.50m3 | 2182*1465*1940 | 2550 | 74 | 650 | 400 | 14.4 | 0.5 | 4.6 | 1250 |
| XG1.SDD-2.0 | 2 | 2 | 1700*1000*1200/2.04m3 | 2062*1792*1990 | 2650 | 107 | 700 | 400 | 19.2 | 0.5 | 4.6 | 1700 |
| XG1.SDG-2.5 | 2 | 2 | 2100*1000*1200/2.52m3 | 2462*1792*1990 | 2900 | 138 | 750 | 400 | 24 | 0.5 | 4.6 | 2100 |
| XG1.SDN-3.0 | 2 | 3 | 2500*1000*1200/3.00m3 | 2862*1792*1990 | 3250 | 159 | 800 | 400 | 28.8 | 0.5 | 6.05 | 2500 |
| XG1.SDO-3.5 | 2 | 3 | 2900*1000*1200/3.48m3 | 3262*1792*1990 | 3450 | 175 | 1060 | 400 | 33.6 | 0.5 | 6.05 | 3000 |
| XG1.SDF-5.0 | 2 | 4 | 4200*1000*1200/5.04m3 | 4562*1792*1990 | 4300 | 277 | 1850 | 350 | 48 | 0.5 | 6.2 | 4300 |
| XG1.SDQ-6.0 | 2 | 5 | 5200*1000*1200/6.24m3 | 5562*1792*1990 | 4500 | 347 | 2000 | 350 | 57.6 | 0.5 | 6.2 | 5500 |
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